Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with rational monomer composition can direct architecture, self-assembly and chemical behavior, ultimately guiding the choic...

Full description

Saved in:
Bibliographic Details
Published in:Chemical Society reviews 2020-07, Vol.49 (14), p.4737-4834
Main Authors: Rasines Mazo, Alicia, Allison-Logan, Stephanie, Karimi, Fatemeh, Chan, Nicholas Jun-An, Qiu, Wenlian, Duan, Wei, O'Brien-Simpson, Neil M, Qiao, Greg G
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - chemistry
Architecture
Biocompatibility
Biodegradability
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
Polymerization
Polypeptides
Ring opening polymerization
Self-assembly
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with rational monomer composition can direct architecture, self-assembly and chemical behavior, ultimately guiding the choice of appropriate application within the biomedical field. This review focuses on the applications of polypeptides alongside the synthetic advances in the ring opening polymerization of α-amino acid N -carboxyanhydrides achieved in the past five years. Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied. This review provides a comprehensive overview of the latest advances in the synthesis, architectural design and biomedical applications of polypeptides and their hybrids.
ISSN:0306-0012
1460-4744
DOI:10.1039/c9cs00738e