Cleaving DNA-model phosphodiester with Lewis acid-base catalytic sites in bifunctional Zr-MOFs

Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P-O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal-organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2019-06, Vol.48 (23), p.844-848
Main Authors: Zhou, Ying-Hua, Zhang, Zhiyan, Patrick, Margaret, Yang, Fan, Wei, Rangling, Cheng, Yong, Gu, Jing
Format: Article
Language:English
Subjects:
Biomolecules
Catalysis
Cleavage
Deoxyribonucleic acid
DNA
Genetic engineering
Lewis acid
Metal-organic frameworks
Molecular biology
Organophosphates
Zirconium
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Summary:Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P-O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal-organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as heterogeneous catalysts for the hydrolytic cleavage of bis( p -nitrophenyl) phosphate (BNPP). UiO-67-bpydc-Zn with isolated multi-catalytic active sites was fabricated as a catalyst for the hydrolysis of bis( p -nitrophenyl) phosphate as a DNA model. The enhanced activity may likely be attributed to the cooperation effects between the Lewis acid from the zirconium center at the node and the zinc hydroxide Lewis base in the linkers.
ISSN:1477-9226
1477-9234
DOI:10.1039/c9dt00246d