Cleaving DNA-model phosphodiester with Lewis acid-base catalytic sites in bifunctional Zr-MOFs

Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P-O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal-organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2019-06, Vol.48 (23), p.844-848
Main Authors: Zhou, Ying-Hua, Zhang, Zhiyan, Patrick, Margaret, Yang, Fan, Wei, Rangling, Cheng, Yong, Gu, Jing
Format: Article
Language:English
Subjects:
Biomolecules
Catalysis
Cleavage
Deoxyribonucleic acid
DNA
Genetic engineering
Lewis acid
Metal-organic frameworks
Molecular biology
Organophosphates
Zirconium
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cited_by cdi_FETCH-LOGICAL-c363t-494223add49485178e28e3a51334118959e1d8cf600cf09d92afd565682074d83
cites cdi_FETCH-LOGICAL-c363t-494223add49485178e28e3a51334118959e1d8cf600cf09d92afd565682074d83
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container_issue 23
container_start_page 844
container_title Dalton transactions : an international journal of inorganic chemistry
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creator Zhou, Ying-Hua
Zhang, Zhiyan
Patrick, Margaret
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Wei, Rangling
Cheng, Yong
Gu, Jing
description Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P-O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal-organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as heterogeneous catalysts for the hydrolytic cleavage of bis( p -nitrophenyl) phosphate (BNPP). UiO-67-bpydc-Zn with isolated multi-catalytic active sites was fabricated as a catalyst for the hydrolysis of bis( p -nitrophenyl) phosphate as a DNA model. The enhanced activity may likely be attributed to the cooperation effects between the Lewis acid from the zirconium center at the node and the zinc hydroxide Lewis base in the linkers.
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Biomolecules
Catalysis
Cleavage
Deoxyribonucleic acid
DNA
Genetic engineering
Lewis acid
Metal-organic frameworks
Molecular biology
Organophosphates
Zirconium
title Cleaving DNA-model phosphodiester with Lewis acid-base catalytic sites in bifunctional Zr-MOFs
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