Black phosphorus-polypyrrole nanocomposites for high-performance photothermal cancer therapy

The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2019-06, Vol.43 (22), p.862-8626
Main Authors: Su, Chengkang, Zhong, Huiqing, Chen, Haolin, Guo, Yanxian, Guo, Zhouyi, Huang, Deqiu, Zhang, Wen, Wu, Qiang, Yang, Biwen, Liu, Zhiming
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Broadband
Cancer
Cancer therapies
Electromagnetic absorption
Morphology
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Near infrared radiation
Phosphorus
Polypyrroles
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo . Black phosphorus-polypyrrole nanosheets with superimposed NIR absorption have been fabricated as the novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy in vitro and in vivo .
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj01249d