Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells

The molecular mechanism of cancer cell death caused by silver nanoparticles (AgNPs) of different sizes is investigated. Compared with the larger nanoparticles, 13 nm AgNPs significantly inhibit the migration and invasiveness of lung adenocarcinoma A549 cells, induce elevated reactive oxygen species...

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Bibliographic Details
Published in:RSC advances 2019-07, Vol.9 (37), p.21134-21138
Main Authors: Que, Yu Mei, Fan, Xiao Qing, Lin, Xiao Juan, Jiang, Xiao Li, Hu, Ping Ping, Tong, Xiao Yong, Tan, Qun You
Format: Article
Language:English
Subjects:
Apoptosis
Cell death
Chemistry
Lung cancer
Nanoparticles
Silver
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Summary:The molecular mechanism of cancer cell death caused by silver nanoparticles (AgNPs) of different sizes is investigated. Compared with the larger nanoparticles, 13 nm AgNPs significantly inhibit the migration and invasiveness of lung adenocarcinoma A549 cells, induce elevated reactive oxygen species and lead to NF-κB directed cellular apoptosis. Size-dependent anti-invasiveness effect of AgNPs was determined using A549 lung adenocarcinoma cells. The 13 nm AgNPs can significantly inhibit the migration and invasion of A549 cells and induce the elevated level of ROS and NF-κB directed cell apoptosis.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra03662h