Independent control over size, valence, and elemental composition in the synthesis of DNA-nanoparticle conjugates

DNA-nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2020-02, Vol.11 (6), p.1564-1572
Main Authors: Bai, Yugang, Xing, Hang, Bai, Yunhao, Tan, Li Huey, Hwang, Kevin, Li, Ji, Lu, Yi, Zimmerman, Steven C
Format: Article
Language:English
Subjects:
Chemical composition
Chemistry
Conjugates
Crosslinking
Deoxyribonucleic acid
DNA
Metathesis
Nanoparticles
Reagents
Self-assembly
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Summary:DNA-nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of DNA-nanoparticle conjugates, based on ring-opening metathesis polymerization (ROMP), intramolecular crosslinking, and template synthesis. Using size, valence, and elemental composition as three independent synthetic parameters, various conjugates can be obtained using a facile and universal procedure. Examples are given to show the usefulness of these conjugates as sensing probes, building blocks for self-assembly, and as model particles for structure-property relationship studies. DNA-nanoparticle conjugates can be synthesized with independent control over size, valence and elemental composition using a template-based strategy.
ISSN:2041-6520
2041-6539
DOI:10.1039/c9sc05656d