Glutathione triggered degradation of polydopamine to facilitate controlled drug release for synergic combinational cancer treatment

Here we report a novel mechanism for triggering drug release in the polydopamine (PDA)-coated magnetic CuCo 2 S 4 core-shell nanostructure by glutathione (GSH) triggered degradation of PDA for release. In the design, we used PDA coated CuCo 2 S 4 as the nanocarrier with polyethylene glycol and folic...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-11, Vol.7 (43), p.6742-675
Main Authors: Hao, Ya-Nan, Zheng, An-Qi, Guo, Ting-Ting, Shu, Yang, Wang, Jian-Hua, Johnson, Omar, Chen, Wei
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Chemotherapy
Controlled release
Core-shell structure
Degradation
Doxorubicin
Drug delivery
Drug delivery systems
Folic acid
Glutathione
Magnetic resonance imaging
Medical imaging
NMR
Nuclear magnetic resonance
Polyethylene glycol
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Summary:Here we report a novel mechanism for triggering drug release in the polydopamine (PDA)-coated magnetic CuCo 2 S 4 core-shell nanostructure by glutathione (GSH) triggered degradation of PDA for release. In the design, we used PDA coated CuCo 2 S 4 as the nanocarrier with polyethylene glycol and folic acid targeting molecules to ensure the safe delivery of doxorubicin (DOX) to cancer cells. In addition, the controlled release could be enforced by taking advantage of the pH sensitivity of PDA to tumor acidic environments. The targeting and treatment of HeLa cancer cells were very effective and the killing was more efficient at higher levels of GSH. Furthermore, the designed system not only could be used for drug delivery but also could combine photothermal therapy with chemotherapy in a synergetic way. Plus, the system could be used for magnetic resonance imaging (MRI), which is beneficial for imaging-guided treatment. Here we report a novel mechanism for triggering drug release in the polydopamine (PDA)-coated magnetic CuCo 2 S 4 core-shell nanostructure by glutathione (GSH) triggered degradation of PDA for release.
ISSN:2050-750X
2050-7518
DOI:10.1039/c9tb01400d