A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

Compared to general fluorescent probes, multi-photon fluorescent probes exhibit deeper tissue penetration, lower auto-fluorescence and lower photo-toxicity in the bio-imaging field. Herein, we synthesized a series multi-photon fluorescent probe ( L1-L3 ) based on quinolone groups. Of notably, the th...

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Bibliographic Details
Published in:Analyst (London) 2021-01, Vol.145 (24), p.7941-7945
Main Authors: Zhang, Sijing, Yang, Zhenghui, Li, Minghao, zhang, Qiong, Tian, Xiaohe, Li, Dandan, Li, Shengli, Wu, Jieying, Tian, Yupeng
Format: Article
Language:English
Subjects:
Droplets
Fluorescent Dyes
Fluorescent indicators
HeLa Cells
Humans
Imaging
Lipid Droplets
Lipids
Photons
Quinoline
Quinolines
Selectivity
Toxicity
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Summary:Compared to general fluorescent probes, multi-photon fluorescent probes exhibit deeper tissue penetration, lower auto-fluorescence and lower photo-toxicity in the bio-imaging field. Herein, we synthesized a series multi-photon fluorescent probe ( L1-L3 ) based on quinolone groups. Of notably, the three-photon fluorescence of L3 significantly enhanced when L3 interacted with liposome; moreover, L3 exhibited high selectivity towards lipid droplets in living cells. Due to its large Stokes shift, high selectivity and photon-stability, L3 was successfully used in lipid droplet imaging via multi-photon fluorescence bio-imaging. Compound L3 possesses excellent two/three photon absorption properties, and has been successfully applied in the bioimaging of LDs.
ISSN:0003-2654
1364-5528
DOI:10.1039/d0an01847c