Azide functionalized porphyrin based dendritic polymers for in vivo monitoring of Hg 2+ ions in living cells

A porphyrin cored azide functionalised dendritic polymer was developed as a selective sensor for in vivo monitoring of mercuric ions in living (normal and cancer) cells and in an aqueous medium. The developed sensor could sense mercuric ions even at a nanomolar concentration with a limit of detectio...

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Bibliographic Details
Published in:Analytical methods 2020-06, Vol.12 (23), p.2995-3003
Main Authors: G, Avudaiappan, Vibija J, Mariya, K, Sreekumar
Format: Article
Language:English
Subjects:
Azides
Dendrimers
Ions
Mercury
Porphyrins
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Summary:A porphyrin cored azide functionalised dendritic polymer was developed as a selective sensor for in vivo monitoring of mercuric ions in living (normal and cancer) cells and in an aqueous medium. The developed sensor could sense mercuric ions even at a nanomolar concentration with a limit of detection value of 0.9 nM. This probe can be used to monitor mercuric ions in living cells due to its low cytotoxicity and high cell permeability. The hydrophilic nature of the polymer makes it a promising candidate for sensing mercuric ions in real water samples. Moreover, the reversibility of this sensing strategy helps in constructing a logic gate, which is particularly useful in smart sensor design.
ISSN:1759-9660
1759-9679
DOI:10.1039/d0ay00769b