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Nanoparticle facilitated delivery of peroxides for effective cancer treatments
Through the utilization of hydrogen peroxide (H 2 O 2 ) in cancer cells, nanoparticle-facilitated catalytic generation of therapeutic molecules such as O 2 and hydroxyl radicals enabled enhanced anticancer efficacy of O 2 or reactive oxygen species-dependent therapies. However, the intracellular H 2...
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| Published in: | Biomaterials science 2020-10, Vol.8 (2), p.5574-5582 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| Summary: | Through the utilization of hydrogen peroxide (H
2
O
2
) in cancer cells, nanoparticle-facilitated catalytic generation of therapeutic molecules such as O
2
and hydroxyl radicals enabled enhanced anticancer efficacy of O
2
or reactive oxygen species-dependent therapies. However, the intracellular H
2
O
2
was inadequate to obtain satisfactory therapeutic outcomes. Although several reagents such as glucose oxidase and cisplatin could promote H
2
O
2
levels by O
2
conversion, H
2
O
2
-mediated therapeutic efficacy was still hindered in the hypoxic tumor microenvironment. Fortunately, exogenous delivery of H
2
O
2
or other peroxides to tumor sites was able to break the limitation of intracellular O
2
and H
2
O
2
levels and enhance anti-tumor effects. In this review, we summarize the recent progress in constructing a peroxide delivery system for cancer treatments and discuss their challenges and potential applications.
Peroxide nanoparticles increase the intratumoral H
2
O
2
concentration for the catalytic production of &z.rad;OH and O
2
, which further enhance O
2
/ROS-dependent anticancer therapies. |
|---|---|
| ISSN: | 2047-4830 2047-4849 |
| DOI: | 10.1039/d0bm01265c |