Calixarene-mediated assembly of water-soluble C 60 -attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells

Unprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C molecules attached on the surfaces have been produced in water in the presence of p-phosphonic acid calix[8]arene. The amphiphilic calixarene plays multiple roles in thes...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (53), p.7325-7328
Main Authors: Mo, Jingxin, Li, Meiying, Chen, Xianjue, Li, Qinghua
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Calixarenes - chemistry
Cell Line, Tumor
Fullerenes - chemistry
Graphite - chemistry
Humans
Lasers
Molecular Conformation
Nanotubes, Carbon - chemistry
Neuroblastoma - drug therapy
Phosphorous Acids - chemistry
Photochemotherapy
Reactive Oxygen Species - metabolism
Solubility
Surface Properties
Water
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Summary:Unprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C molecules attached on the surfaces have been produced in water in the presence of p-phosphonic acid calix[8]arene. The amphiphilic calixarene plays multiple roles in these processes to provide water dispersibility and π-π interactions with flexible conformations complementing curvatures of the carbon surfaces. The significantly increased water solubility and area of exposure of C enable efficient activation of reactive oxygen species for enhanced phototoxicity to SH-SY5Y human neuroblastoma cell line under laser irradiation.
ISSN:1359-7345
1364-548X
DOI:10.1039/D0CC01921F