Growth and inhibition of monohydrate sodium urate banded spherulites

Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera, Nat. Rev. Rheumatol. , 2015, 11, 725) with limited understanding. M...

Full description

Saved in:
Bibliographic Details
Published in:CrystEngComm 2021-02, Vol.23 (6), p.1439-1446
Main Authors: Zhou, Yao, Feng, Xiaowei, Wang, Ting, Tian, Yang, Cui, Xiaoyan
Format: Article
Language:English
Subjects:
Additives
Arthritis
Crystal structure
Crystallinity
Deposition
Flat surfaces
Morphology
Raman spectra
Spherulites
Twisting
X ray spectra
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera, Nat. Rev. Rheumatol. , 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces. The growth and inhibition of banded monosodium urate spherulites are explored in detail.
ISSN:1466-8033
1466-8033
DOI:10.1039/d0ce01378a