Scalable biocatalytic C-H oxyfunctionalization reactions

Catalytic C-H oxyfunctionalization reactions have garnered significant attention in recent years with their ability to streamline synthetic routes toward complex molecules. Consequently, there have been significant strides in the design and development of catalysts that enable diversification throug...

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Bibliographic Details
Published in:Chemical Society reviews 2020-11, Vol.49 (22), p.8137-8155
Main Authors: Chakrabarty, Suman, Wang, Ye, Perkins, Jonathan C, Narayan, Alison R. H
Format: Article
Language:English
Subjects:
Biocatalysis
Cytochrome P-450 Enzyme System - metabolism
Molecular Structure
Oxygenases - metabolism
Oxygenation
Small Molecule Libraries - chemistry
Small Molecule Libraries - metabolism
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Summary:Catalytic C-H oxyfunctionalization reactions have garnered significant attention in recent years with their ability to streamline synthetic routes toward complex molecules. Consequently, there have been significant strides in the design and development of catalysts that enable diversification through C-H functionalization reactions. Enzymatic C-H oxygenation reactions are often complementary to small molecule based synthetic approaches, providing a powerful tool when deployable on preparative-scale. This review highlights key advances in scalable biocatalytic C-H oxyfunctionalization reactions developed within the past decade. Biocatalytic methods for selective C-H oxyfunctionalization reactions are rapidly emerging and hold significant potential to streamline complex molecule synthesis. This review highlights key advances in this area developed within the past decade.
ISSN:0306-0012
1460-4744
DOI:10.1039/d0cs00440e