Structural insights into the recognition of DNA defects by small molecules

Studies on the binding interaction of small molecules and nucleic acids have been explored for their biological applications. With excellent photophysical/chemical properties, numerous metal complexes have been studied as structural probes for nucleic acids. The recognition of DNA defects is of high...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2021-05, Vol.5 (17), p.5691-5712
Main Authors: Dayanidhi, P. David, Vaidyanathan, V. G
Format: Article
Language:English
Subjects:
Adducts
Chemical properties
Coordination Complexes - chemistry
Coordination compounds
Defects
Deoxyribonucleic acid
DNA
DNA - chemistry
Humans
Ligands
Nucleic acids
Recognition
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
Transition metal compounds
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Summary:Studies on the binding interaction of small molecules and nucleic acids have been explored for their biological applications. With excellent photophysical/chemical properties, numerous metal complexes have been studied as structural probes for nucleic acids. The recognition of DNA defects is of high importance due to their association with various types of cancers. Small molecules that target DNA defects in a specific and selective manner offer a new avenue for developing novel drugs and diagnostic tools. Transition metal complexes have been studied as probes for abasic sites and DNA/RNA mismatches. By changing the ligand structure or metal center, the probing efficiency of the metal complexes varies towards the defects. In this perspective, we have discussed mainly the structural requirement of metal complexes as probes for abasic sites, mismatches, and covalent DNA adducts, followed by the challenges and future directions. In this review, we have underlined the application of transition metal chemistry in biological systems.
ISSN:1477-9226
1477-9234
1477-9234
DOI:10.1039/d0dt04289g