Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations

Finger millet (FM) and kodo millet (KM) are known for their multiple health benefits. Several studies have indicated the antioxidant and hypoglycemic potential of polyphenol rich extracts (PREs) from them. However, the protective roles of PREs from these millets in overcoming high-fat diet (HFD)-ind...

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Bibliographic Details
Published in:Food & function 2020-11, Vol.11 (11), p.9833-9847
Main Authors: Khare, Pragyanshu, Maurya, Ruchika, Bhatia, Ruchika, Mangal, Priyanka, Singh, Jagdeep, Podili, Koteswaraiah, Bishnoi, Mahendra, Kondepudi, Kanthi Kiran
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - drug effects
Animals
Antioxidants
Body weight gain
Catechin
Complications
Diet
Diet, High-Fat
Dyslipidemias - prevention & control
Fatty liver
Functional Food
Functional foods & nutraceuticals
High fat diet
High-performance liquid chromatography
Hypertrophy
Lipopolysaccharides
Liquid chromatography
Macrophages
Male
Metabolism
Mice
Millet
Millets
Obesity
Plant Extracts - pharmacology
Polyphenols
Polyphenols - pharmacology
Steatosis
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Summary:Finger millet (FM) and kodo millet (KM) are known for their multiple health benefits. Several studies have indicated the antioxidant and hypoglycemic potential of polyphenol rich extracts (PREs) from them. However, the protective roles of PREs from these millets in overcoming high-fat diet (HFD)-induced obesity have not yet been investigated. This study aimed to identify the polyphenols in FM-PREs and KM-PREs using HPLC-DAD/ESI-MS, and to evaluate the role of PREs in mitigating lipopolysaccharide induced inflammation in murine macrophage cells and in the reduction of HFD-induced metabolic complications using male Swiss albino mice. The results suggested that KM-PRE had higher polyphenol content than FM-PRE, of which taxifolin (98%) and catechin (86.6%) were the major fractions respectively. FM-PRE and KM-PRE prevented obesity, however, KM-PRE was more profound in preventing weight gain, adipose tissue hypertrophy, hepatic steatosis, and systemic inflammation than FM-PRE. This study suggests that FM-PRE and KM-PRE could be exploited for developing functional foods or nutraceuticals against obesity and comorbidities. Taxifolin (98%) and catechin (86.6%) are the major polyphenols in KM-PRE and FM-PRE. FM-PRE and KM-PRE prevent obesity, hepatic steatosis, and gut bacterial dysbiosis however, the effects of KM-PRE are more profound compared to FM-PRE.
ISSN:2042-6496
2042-650X
DOI:10.1039/d0fo01643h