Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions has been developed. This simple and practical approach is environment-friendly and compatible with oxygen/water and various complex biological media. It features excellent regioselectivities and...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2020-01, Vol.22 (8), p.2394-2398
Main Authors: Li, Ming, Zheng, Nan, Li, Junhao, Zheng, Yubin, Song, Wangze
Format: Article
Language:English
Subjects:
Aqueous solutions
Biocompatibility
Carbohydrates
Chemical synthesis
Disulfides
Green chemistry
Iridium
Nanoparticles
Regioselectivity
Triazoles
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Summary:An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions has been developed. This simple and practical approach is environment-friendly and compatible with oxygen/water and various complex biological media. It features excellent regioselectivities and chemoselectivities, high yields, good biocompatibility and bioorthogonality. Its applications in the synthesis of carbohydrates and trigger-responsive nanoparticles are further highlights of this aqueous transformation. Triazole disulfides were prepared in water or biological media under mild conditions by orthogonal and regioselective Ir-catalyzed reactions.
ISSN:1463-9262
1463-9270
DOI:10.1039/d0gc00555j