Environmentally sustainable production and application of acyl phosphates

A versatile and environmentally friendly synthetic method for the formation of acyl phosphates is reported. By employing electrochemical oxidative dehydrogenative coupling, this transformation features a broad range of substrates, as well as metal-free, oxidant-free and mild conditions. One-pot synt...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2020-11, Vol.22 (21), p.7343-7347
Main Authors: Guo, Shengmei, Li, Sen, Yan, Wenjie, Liang, Zhibin, Fu, Zhengjiang, Cai, Hu
Format: Article
Language:English
Subjects:
Additives
Amides
Amines
Catalysts
Dehydrogenation
Electrochemistry
Green chemistry
Oxidants
Oxidizing agents
Phosphates
Regioselectivity
Room temperature
Substrates
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Summary:A versatile and environmentally friendly synthetic method for the formation of acyl phosphates is reported. By employing electrochemical oxidative dehydrogenative coupling, this transformation features a broad range of substrates, as well as metal-free, oxidant-free and mild conditions. One-pot synthesis of amides from acyl phosphates with amines was accomplished with high efficiency and regioselectivity, without using any additional catalysts and additives, within 2 hours under room temperature. The mechanism is proposed according to the control experiments. A versatile and environmentally friendly synthetic method for the formation of acyl phosphates is reported.
ISSN:1463-9262
1463-9270
DOI:10.1039/d0gc02370a