Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices

Microfluidic technologies offer a number of advantages for sample preparation in point-of-care testing (POCT), but the requirement for complicated external pumping systems limits their wide use. To facilitate sample preparation in POCT, various methods have been developed to operate microfluidic dev...

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Bibliographic Details
Published in:Lab on a chip 2020-04, Vol.2 (7), p.1191-123
Main Authors: Park, Juhwan, Han, Dong Hyun, Park, Je-Kyun
Format: Article
Language:English
Subjects:
Actuation
Capillary pressure
Chemical reactions
Devices
Microchannels
Microfluidic devices
Point of care testing
Power sources
Pumping
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Summary:Microfluidic technologies offer a number of advantages for sample preparation in point-of-care testing (POCT), but the requirement for complicated external pumping systems limits their wide use. To facilitate sample preparation in POCT, various methods have been developed to operate microfluidic devices without complicated external pumping systems. In this review, we introduce an overview of user-friendly microfluidic devices for practical sample preparation in POCT, including self- and hand-operated microfluidic devices. Self-operated microfluidic devices exploit capillary force, vacuum-driven pressure, or gas-generating chemical reactions to apply pressure into microchannels, and hand-operated microfluidic devices utilize human power sources using simple equipment, including a syringe, pipette, or simply by using finger actuation. Furthermore, this review provides future perspectives to realize user-friendly integrated microfluidic circuits for wider applications with the integration of simple microfluidic valves. An overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.
ISSN:1473-0197
1473-0189
DOI:10.1039/d0lc00047g