MOF-5 as a highly efficient and recyclable catalyst for one pot synthesis of 2,4-disubstituted quinoline derivatives

A MOF-5-catalyzed three-component coupling reaction was developed as an efficient approach for the synthesis of 2,4-disubstituted quinoline derivatives via a one pot three-component reaction of aromatic amines, aldehydes and alkynes with excellent yields. The easy recovery and reusability of the cat...

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Bibliographic Details
Published in:New journal of chemistry 2020-05, Vol.44 (2), p.8614-862
Main Authors: Xiao, Song-Tao, Ma, Cui-Ting, Di, Jia-Qi, Zhang, Zhan-Hui
Format: Article
Language:English
Subjects:
Aldehydes
Alkynes
Amines
Catalysts
Chemical synthesis
Coupling (molecular)
Derivatives
Economic conditions
NMR
Nuclear magnetic resonance
Quinoline
Reaction time
Substrates
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Summary:A MOF-5-catalyzed three-component coupling reaction was developed as an efficient approach for the synthesis of 2,4-disubstituted quinoline derivatives via a one pot three-component reaction of aromatic amines, aldehydes and alkynes with excellent yields. The easy recovery and reusability of the catalyst, broad substrate scope, short reaction time, high yields of products and solvent-free conditions make this protocol practical, environmentally friendly and economically attractive. An approach was developed for the synthesis of 2,4-disubstituted quinoline derivatives via a one pot three-component reaction of aromatic amines, aldehydes and alkynes catalyzed by MOF-5 under solvent-free conditions.
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj01301c