Biodegradable FeWO x nanoparticles for CT/MR imaging-guided synergistic photothermal, photodynamic, and chemodynamic therapy

• Published in: Nanoscale 2021-02, Vol.13 (5), p.3049-3060
• Main Authors: Cheng, Yaru, Lu, Huiting, Yang, Fan, Zhang, Yiyi, Dong, Haifeng
• Format: Article
• Language: English
• Subjects: Cell Line, Tumor; Hydrogen Peroxide; Magnetic Resonance Imaging; Nanoparticles; Tomography, X-Ray Computed
• ISSN: 2040-3364; 2040-3372
• DOI: 10.1039/d0nr07215j

The development of a simple and effective single constituent multifunctional nanotheranostic platform producing a multimodality diagnostic signal and curing effect is still a challenge. Herein, we synthesized simple and biodegradable FeWO ternary oxide nanoparticles and modified their surface with RGD-PEG-NH (FeWO -PEG-RGD NPs), whereby resulting NPs possessed a (T /T ) switchable MRI/CT dual-modal imaging ability and synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) capacity. We showed that FeWO -PEG-RGD NPs enabled tumor accumulation under a magnetic field drive and RGD-mediated tumor penetration and implemented PTT/PDT treatment under 980 nm laser irradiation. In an acidic tumor microenvironment (TME) with a high hydrogen peroxide (H O ) expression, NPs degraded to release Fe and Fe , triggering a Fenton reaction to generate ˙OH for CDT. The released Fe led to T /T signal conversion for tracing cancer therapy, while the high X-ray attenuation coefficient of W also made it a good CT contrast agent for guided therapy. Thus, the structurally simple FeWO -PEG-RGD was capable of mediating (T /T -weighted) MR/CT two modal imaging-guided PTT/PDT/CDT synergic therapy with a high accuracy and superb anticancer efficiency. The simple, degradable, rapid-clearance, and multifunctional FeWO -PEG-RGD NPs provide a novel, promising, and versatile nanotheranostic platform.