Removal and modification of directing groups used in metal-catalyzed C-H functionalization: the magical step of conversion into 'conventional' functional groups

Over the past few decades, regioselective catalytic C-H functionalization has provided an attractive tool for unique retrosynthetic disconnections. The advancement of the directing group strategy in metal catalyzed synthetic transformation has contributed significantly to the incorporation of a wide...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2021-01, Vol.19 (3), p.525-547
Main Authors: Carvalho, Renato L, Almeida, Renata G, Murali, Karunanidhi, Machado, Luana A, Pedrosa, Leandro F, Dolui, Pravas, Maiti, Debabrata, da Silva Júnior, Eufrânio N
Format: Article
Language:English
Subjects:
Functional groups
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Summary:Over the past few decades, regioselective catalytic C-H functionalization has provided an attractive tool for unique retrosynthetic disconnections. The advancement of the directing group strategy in metal catalyzed synthetic transformation has contributed significantly to the incorporation of a wide range of functionalization reactions in both aromatic systems and aliphatic backbones. However, the extensive utilization of these methodologies depends on the ease of removal of the directing group to restore the free functional group. In this review, we have summarised the reported approaches for removing/modifying versatile directing groups. This feature review is focused on recent approaches for removing versatile directing groups.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob02232b