Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

Light-triggered drug release from hydrogels is a promising method to improve efficiency of antitumor treatment, as an alternative to existing photodynamic therapies. Here we report a photochromic supramolecular low-MW hydrogel that can quickly and selectively release a physically encapsulated potent...

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Bibliographic Details
Published in:RSC advances 2021-02, Vol.11 (15), p.8546-8551
Main Authors: Karcher, Johannes, Kirchner, Susanne, Leistner, Anna-Lena, Hald, Christian, Geng, Philipp, Bantle, Tobias, Gödtel, Peter, Pfeifer, Juliana, Pianowski, Zbigniew L
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Hydrogels
Light irradiation
Photochromism
Rheological properties
Rheology
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Summary:Light-triggered drug release from hydrogels is a promising method to improve efficiency of antitumor treatment, as an alternative to existing photodynamic therapies. Here we report a photochromic supramolecular low-MW hydrogel that can quickly and selectively release a physically encapsulated potent anticancer agent upon green light irradiation under physiological conditions. Selective green-light triggered release of an anticancer agent under physiological conditions from a supramolecular hydrogel.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra08893e