Current advances in nanomaterials affecting morphology, structure, and function of erythrocytes

In recent decades, nanomaterials have been widely used in the field of biomedicine due to their unique physical and chemical properties, and have shown good prospects for in vitro diagnosis, drug delivery, and imaging. With regard to transporting nanoparticles (NPs) to target tissues or organs in th...

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Bibliographic Details
Published in:RSC advances 2021-02, Vol.11 (12), p.6958-6971
Main Authors: Tian, Yaxian, Tian, Zhaoju, Dong, Yanrong, Wang, Xiaohui, Zhan, Linsheng
Format: Article
Language:English
Subjects:
Biocompatibility
Chemical properties
Chemistry
Drug carriers
Erythrocytes
Membranes
Morphology
Nanomaterials
Nanoparticles
Organs
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Summary:In recent decades, nanomaterials have been widely used in the field of biomedicine due to their unique physical and chemical properties, and have shown good prospects for in vitro diagnosis, drug delivery, and imaging. With regard to transporting nanoparticles (NPs) to target tissues or organs in the body intravenously or otherwise, blood is the first tissue that NPs come into contact with and is also considered an important gateway for targeted transport. Erythrocytes are the most numerous cells in the blood, but previous studies based on interactions between erythrocytes and NPs mostly focused on the use of erythrocytes as drug carriers for nanomedicine which were chemically bound or physically adsorbed by NPs, so little is known about the effects of nanoparticles on the morphology, structure, function, and circulation time of erythrocytes in the body. Herein, this review focuses on the mechanisms by which nanoparticles affect the structure and function of erythrocyte membranes, involving the hemocompatibility of NPs, the way that NPs interact with erythrocyte membranes, effects of NPs on erythrocyte surface membrane proteins and their structural morphology and the effect of NPs on erythrocyte lifespan and function. The detailed analysis in this review is expected to shed light on the more advanced biocompatibility of nanomaterials and pave the way for the development of new nanodrugs. This review focuses on the way how nanoparticles affect the structure and function of erythrocyte membranes, and is expected to pave the way for development of new nanodrugs.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra10124a