Self-assembly of paramagnetic amphiphilic copolymers for synergistic therapy

Engineering nanoparticles (NPs) with multifunctionality has become a promising strategy for cancer theranostics. Herein, theranostic polymer NPs are fabricated via the assembly of amphiphilic paramagnetic block copolymers (PCL- b -PIEtMn), in which IR-780 and doxorubicin (DOX) were co-encapsulated,...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-08, Vol.8 (31), p.6866-6876
Main Authors: Gao, Zhiliang, Mu, Weiwei, Tian, Yuan, Su, Yimao, Sun, Huanli, Zhang, Gaorui, Li, Anning, Yu, Dexin, Zhang, Na, Hao, Jingcheng, Liu, Yongjun, Cui, Jiwei
Format: Article
Language:English
Subjects:
Block copolymers
Chemotherapy
Copolymers
Doxorubicin
Doxorubicin - pharmacology
Drug delivery
Drug delivery systems
Drug Synergism
Encapsulation
Fluorescence
Humans
Hydrophobic and Hydrophilic Interactions
Infrared imaging
Irradiation
Magnetic resonance
Magnets - chemistry
MCF-7 Cells
Nanoparticles
Nanoparticles - chemistry
Near infrared radiation
Optical Imaging
Phototherapy
Polymers
Polymers - chemistry
Polymers - therapeutic use
Precision medicine
Self-assembly
Tumors
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Summary:Engineering nanoparticles (NPs) with multifunctionality has become a promising strategy for cancer theranostics. Herein, theranostic polymer NPs are fabricated via the assembly of amphiphilic paramagnetic block copolymers (PCL- b -PIEtMn), in which IR-780 and doxorubicin (DOX) were co-encapsulated, for magnetic resonance (MR) and near infrared fluorescence (NIRF) imaging as well as for photo thermal therapy (PTT)-enhanced chemotherapy. The synthesized amphiphilic paramagnetic block copolymers demonstrated high relaxivity ( r 1 = 7.05 mM −1 s −1 ). The encapsulated DOX could be released with the trigger of near infrared (NIR) light. In vivo imaging confirmed that the paramagnetic NPs could be accumulated effectively at the tumor sites. Upon the NIR laser irradiation, tumor growth was inhibited by PTT-enhanced chemotherapy. The advantages of the reported system lie in the one-step convergence of multiple functions ( i.e. , imaging and therapy agents) into a one delivery vehicle and the dual mode imaging-guided synergistic PTT and chemotherapy. This study represents a new drug delivery vehicle of paramagnetic NPs for visualized theranostics. Theranostic nanoparticles composed of amphiphilic paramagnetic polymers are assembled for dual mode imaging and synergistic therapy.
ISSN:2050-750X
2050-7518
DOI:10.1039/d0tb00405g