Zinc catalysed C3-H borylation of indoles and 1,1-diboration of terminal alkynes

A low catalyst loading Zn(OTf) 2 -catalysed C3-H borylation of indoles with pinacolborane was developed. This transformation represents the use of an abundant, cheap and environmentally benign zinc catalyst in catalytic direct aromatic C-H borylation and offers a simple and prompt route towards the...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (85), p.11185-11188
Main Authors: Zhang, Binfeng, Zou, Youliang, Wang, Li, Zhang, Hua
Format: Article
Language:English
Subjects:
Alkenes
Alkynes
Catalysts
Indoles
Zinc
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Summary:A low catalyst loading Zn(OTf) 2 -catalysed C3-H borylation of indoles with pinacolborane was developed. This transformation represents the use of an abundant, cheap and environmentally benign zinc catalyst in catalytic direct aromatic C-H borylation and offers a simple and prompt route towards the synthesis of C3-borylated indoles. The 1,1-diboration of terminal alkynes was also achieved using the same catalytic system to produce 1,1-diborylated alkenes. Zn(OTf) 2 -catalysed C3-H borylation of indoles and 1,1-diboration of terminal alkynes has been realized for the simple and prompt synthesis of C3-borylated indoles and 1,1-diborylated alkenes.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc04497d