Photoredox catalyzed cascade CF 3 addition/chemodivergent annulations of ortho -alkenyl aryl ureas

Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versa...

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Published in:Chemical communications (Cambridge, England) England), 2022-02, Vol.58 (12), p.1990-1993
Main Authors: Babu, Sakamuri Sarath, Varma, A Anagha, Gopinath, Purushothaman
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Language:English
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container_end_page 1993
container_issue 12
container_start_page 1990
container_title Chemical communications (Cambridge, England)
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creator Babu, Sakamuri Sarath
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description Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.
doi_str_mv 10.1039/D1CC06289A
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title Photoredox catalyzed cascade CF 3 addition/chemodivergent annulations of ortho -alkenyl aryl ureas
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