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Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways
Osteoarthritis (OA), a degenerative disease, has attracted extensive attention all over the world. In this study, a rat model involving medial meniscus resection (MMx) and anterior to medial collateral ligament (ACL) operation was successfully established to study the effects of bovine cartilage hyd...
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| Published in: | Food & function 2022-02, Vol.13 (3), p.1192-125 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c337t-ca879d6c18d9117a184118d23e730bbbd8982df31dc84a8ec54ef14f1d55fc833 |
| container_end_page | 125 |
| container_issue | 3 |
| container_start_page | 1192 |
| container_title | Food & function |
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| creator | Hao, Li Ma, Chengcheng Li, Zhaoxia Wang, Yanchao Zhao, Xue Yu, Mingxiao Hou, Hu |
| description | Osteoarthritis (OA), a degenerative disease, has attracted extensive attention all over the world. In this study, a rat model involving medial meniscus resection (MMx) and anterior to medial collateral ligament (ACL) operation was successfully established to study the effects of bovine cartilage hydrolysates rich in type II collagen peptides (BIIP) on cartilage protection. The results of histological analysis indicated that oral administration of BIIP at doses of 200 and 500 mg kg
−1
d
−1
ameliorated cartilage degeneration. Moreover, the potential targets of BIIP affecting OA
in vivo
were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-κB, Wnt/β-catenin and MAPK, were further explored at mRNA and protein levels. BIIP downregulated the expression of IL-6, RUNX2, NF-κB p65, HIF-2α, β-catenin and p-JNK, which may be the main factor leading to the prevention of OA. These results suggest that BIIP can be used as a novel potential substance of functional foods to exert chondroprotective action.
Type II collagen peptides could significantly influence OA. |
| doi_str_mv | 10.1039/d1fo03414f |
| format | article |
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−1
d
−1
ameliorated cartilage degeneration. Moreover, the potential targets of BIIP affecting OA
in vivo
were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-κB, Wnt/β-catenin and MAPK, were further explored at mRNA and protein levels. BIIP downregulated the expression of IL-6, RUNX2, NF-κB p65, HIF-2α, β-catenin and p-JNK, which may be the main factor leading to the prevention of OA. These results suggest that BIIP can be used as a novel potential substance of functional foods to exert chondroprotective action.
Type II collagen peptides could significantly influence OA.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo03414f</identifier><identifier>PMID: 35018959</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Arthritis ; beta Catenin - metabolism ; Biomedical materials ; Cartilage ; Cartilage diseases ; Cbfa-1 protein ; Cells, Cultured ; Collagen ; Collagen (type II) ; Collagen Type II - metabolism ; Degeneration ; Disease Models, Animal ; Female ; Functional foods & nutraceuticals ; Hydrolysates ; Interleukin 6 ; Knee ; MAP kinase ; Meniscus ; Mitogen-Activated Protein Kinase Kinases - metabolism ; mRNA ; NF-kappa B - metabolism ; NF-κB protein ; Oral administration ; Osteoarthritis ; Osteoarthritis - metabolism ; Peptides ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Wnt protein ; Wnt Signaling Pathway ; β-Catenin</subject><ispartof>Food & function, 2022-02, Vol.13 (3), p.1192-125</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-ca879d6c18d9117a184118d23e730bbbd8982df31dc84a8ec54ef14f1d55fc833</citedby><cites>FETCH-LOGICAL-c337t-ca879d6c18d9117a184118d23e730bbbd8982df31dc84a8ec54ef14f1d55fc833</cites><orcidid>0000-0002-7754-4116 ; 0000-0003-1855-2543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35018959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Li</creatorcontrib><creatorcontrib>Ma, Chengcheng</creatorcontrib><creatorcontrib>Li, Zhaoxia</creatorcontrib><creatorcontrib>Wang, Yanchao</creatorcontrib><creatorcontrib>Zhao, Xue</creatorcontrib><creatorcontrib>Yu, Mingxiao</creatorcontrib><creatorcontrib>Hou, Hu</creatorcontrib><title>Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Osteoarthritis (OA), a degenerative disease, has attracted extensive attention all over the world. In this study, a rat model involving medial meniscus resection (MMx) and anterior to medial collateral ligament (ACL) operation was successfully established to study the effects of bovine cartilage hydrolysates rich in type II collagen peptides (BIIP) on cartilage protection. The results of histological analysis indicated that oral administration of BIIP at doses of 200 and 500 mg kg
−1
d
−1
ameliorated cartilage degeneration. Moreover, the potential targets of BIIP affecting OA
in vivo
were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-κB, Wnt/β-catenin and MAPK, were further explored at mRNA and protein levels. BIIP downregulated the expression of IL-6, RUNX2, NF-κB p65, HIF-2α, β-catenin and p-JNK, which may be the main factor leading to the prevention of OA. These results suggest that BIIP can be used as a novel potential substance of functional foods to exert chondroprotective action.
Type II collagen peptides could significantly influence OA.</description><subject>Animals</subject><subject>Arthritis</subject><subject>beta Catenin - metabolism</subject><subject>Biomedical materials</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Cbfa-1 protein</subject><subject>Cells, Cultured</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Collagen Type II - metabolism</subject><subject>Degeneration</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Functional foods & nutraceuticals</subject><subject>Hydrolysates</subject><subject>Interleukin 6</subject><subject>Knee</subject><subject>MAP kinase</subject><subject>Meniscus</subject><subject>Mitogen-Activated Protein Kinase Kinases - metabolism</subject><subject>mRNA</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Oral administration</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - metabolism</subject><subject>Peptides</subject><subject>Proteomics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Wnt protein</subject><subject>Wnt Signaling Pathway</subject><subject>β-Catenin</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkclKBDEQhoMoKurFuxLwImJrqtPpSY5uo4PrQdFbk8nitMx0xiSN9Gt59CF8JqPjAtblL6iviqr6EVoHsgeEin0N1hFaQGHn0HJOijwrGXmY_8kLUS6htRCeSAoqBBd8ES1RRoALJpaRO7HWqBiwszh2U4MHA6zceCwfTYNHnfZu3AUZTQIa7EI0Tvo48nWsA07q2sdRUoOv-tn72-Euvm_i_vtrplJLUzdYNhpfHtyc46mMoxfZhVW0YOU4mLVvXUF3_ZPbo7Ps4vp0cHRwkSlKezH1857QpQKuBUBPAi8g5Tk1PUqGw6FOd-TaUtCKF5IbxQpj0w9AM2YVp3QFbc_mTr17bk2I1aQOyqTDGuPaUOUliBxKBnlCt_6hT671TdouUXlJeMEYT9TOjFLeheCNraa-nkjfVUCqTyeqY-hffznRT_Dm98h2ODH6F_35ewI2ZoAP6rf6ZyX9AMZojeo</recordid><startdate>20220207</startdate><enddate>20220207</enddate><creator>Hao, Li</creator><creator>Ma, Chengcheng</creator><creator>Li, Zhaoxia</creator><creator>Wang, Yanchao</creator><creator>Zhao, Xue</creator><creator>Yu, Mingxiao</creator><creator>Hou, Hu</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7754-4116</orcidid><orcidid>https://orcid.org/0000-0003-1855-2543</orcidid></search><sort><creationdate>20220207</creationdate><title>Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways</title><author>Hao, Li ; Ma, Chengcheng ; Li, Zhaoxia ; Wang, Yanchao ; Zhao, Xue ; Yu, Mingxiao ; Hou, Hu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-ca879d6c18d9117a184118d23e730bbbd8982df31dc84a8ec54ef14f1d55fc833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Arthritis</topic><topic>beta Catenin - metabolism</topic><topic>Biomedical materials</topic><topic>Cartilage</topic><topic>Cartilage diseases</topic><topic>Cbfa-1 protein</topic><topic>Cells, Cultured</topic><topic>Collagen</topic><topic>Collagen (type II)</topic><topic>Collagen Type II - metabolism</topic><topic>Degeneration</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Functional foods & nutraceuticals</topic><topic>Hydrolysates</topic><topic>Interleukin 6</topic><topic>Knee</topic><topic>MAP kinase</topic><topic>Meniscus</topic><topic>Mitogen-Activated Protein Kinase Kinases - metabolism</topic><topic>mRNA</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Oral administration</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - metabolism</topic><topic>Peptides</topic><topic>Proteomics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Wnt protein</topic><topic>Wnt Signaling Pathway</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Li</creatorcontrib><creatorcontrib>Ma, Chengcheng</creatorcontrib><creatorcontrib>Li, Zhaoxia</creatorcontrib><creatorcontrib>Wang, Yanchao</creatorcontrib><creatorcontrib>Zhao, Xue</creatorcontrib><creatorcontrib>Yu, Mingxiao</creatorcontrib><creatorcontrib>Hou, Hu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Li</au><au>Ma, Chengcheng</au><au>Li, Zhaoxia</au><au>Wang, Yanchao</au><au>Zhao, Xue</au><au>Yu, Mingxiao</au><au>Hou, Hu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2022-02-07</date><risdate>2022</risdate><volume>13</volume><issue>3</issue><spage>1192</spage><epage>125</epage><pages>1192-125</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Osteoarthritis (OA), a degenerative disease, has attracted extensive attention all over the world. In this study, a rat model involving medial meniscus resection (MMx) and anterior to medial collateral ligament (ACL) operation was successfully established to study the effects of bovine cartilage hydrolysates rich in type II collagen peptides (BIIP) on cartilage protection. The results of histological analysis indicated that oral administration of BIIP at doses of 200 and 500 mg kg
−1
d
−1
ameliorated cartilage degeneration. Moreover, the potential targets of BIIP affecting OA
in vivo
were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-κB, Wnt/β-catenin and MAPK, were further explored at mRNA and protein levels. BIIP downregulated the expression of IL-6, RUNX2, NF-κB p65, HIF-2α, β-catenin and p-JNK, which may be the main factor leading to the prevention of OA. These results suggest that BIIP can be used as a novel potential substance of functional foods to exert chondroprotective action.
Type II collagen peptides could significantly influence OA.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35018959</pmid><doi>10.1039/d1fo03414f</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7754-4116</orcidid><orcidid>https://orcid.org/0000-0003-1855-2543</orcidid></addata></record> |
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| ispartof | Food & function, 2022-02, Vol.13 (3), p.1192-125 |
| issn | 2042-6496 2042-650X |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Animals Arthritis beta Catenin - metabolism Biomedical materials Cartilage Cartilage diseases Cbfa-1 protein Cells, Cultured Collagen Collagen (type II) Collagen Type II - metabolism Degeneration Disease Models, Animal Female Functional foods & nutraceuticals Hydrolysates Interleukin 6 Knee MAP kinase Meniscus Mitogen-Activated Protein Kinase Kinases - metabolism mRNA NF-kappa B - metabolism NF-κB protein Oral administration Osteoarthritis Osteoarthritis - metabolism Peptides Proteomics Rats Rats, Sprague-Dawley Wnt protein Wnt Signaling Pathway β-Catenin |
| title | Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways |
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