A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst

• Published in: Green chemistry : an international journal and green chemistry resource : GC 2021-11, Vol.23 (23), p.9439-9446
• Main Authors: Vasu, Amrutham, Naresh, Mameda, Krishna Sai, Gajula, Divya Rohini, Yennamaneni, Murali, Boosa, Ramulamma, Madasu, Ramunaidu, Addipilli, Narender, Nama
• Format: Article
• Language: English
• Subjects: Amines; Benzimidazoles; Catalysts; Chemical synthesis; Green chemistry; Industrial applications; Quinoxaline; Quinoxalines; Substrates
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/d1gc02627e

This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various analytical techniques. The probability and limitations of the catalytic methodology were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications. This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions.