Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

Two green strategies for copper-catalyzed azide-alkyne cycloaddition reaction based on two activation pathways, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, are reported for the synthesis of glucuronic acid glycodendrimers with good conversions (99%), the MW...

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Bibliographic Details
Published in:New journal of chemistry 2022-04, Vol.46 (14), p.6389-6393
Main Authors: García-Oliva, Cecilia, Merchán, Alejandro, Perona, Almudena, Hoyos, Pilar, Rumbero, Ángel, Hernáiz, María J
Format: Article
Language:English
Subjects:
Alkynes
Ball milling
Cycloaddition
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Summary:Two green strategies for copper-catalyzed azide-alkyne cycloaddition reaction based on two activation pathways, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, are reported for the synthesis of glucuronic acid glycodendrimers with good conversions (99%), the MW pathway being the ideal tool (90% yield in 90 min). Two green strategies for CuAAC reaction based on two activation pathways, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, are reported for the synthesis of glucuronic acid glycodendrimers with good conversión.
ISSN:1144-0546
1369-9261
DOI:10.1039/d1nj06132a