The synthesis of aryl-heteroaryl derivatives via the Rh III -catalyzed heteroarylation of arenes and heteroaromatic boronates

An efficient Rh -catalyzed strategy for constructing aryl-heteroaryl derivatives with removable ketoxime ether auxiliaries direct C-H heteroarylation based on arenes and heteroaromatic boronates has been disclosed. This protocol could tolerate various pyridine, pyrimidine, pyrazole, thiophene, and f...

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Published in:Organic & biomolecular chemistry 2022-01, Vol.20 (3), p.686-693
Main Authors: Wang, Huai-Wei, Wu, Jia-Xue, Li, Da-Cheng, Qiao, Yu-Han, Yao, Qing-Xia, Sun, Wen-Can, Dou, Jian-Min
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cited_by cdi_FETCH-LOGICAL-c184t-cee4e05805a0c463dbfe815d637eeff98ec3f349cb37fbdfeffb33e39dee65183
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description An efficient Rh -catalyzed strategy for constructing aryl-heteroaryl derivatives with removable ketoxime ether auxiliaries direct C-H heteroarylation based on arenes and heteroaromatic boronates has been disclosed. This protocol could tolerate various pyridine, pyrimidine, pyrazole, thiophene, and furan heteroaromatic boronates well, providing the desired products with high reactivities and excellent regioselectivity. The easy synthetic accessibility may offer potential for application in the synthesis of heterocyclic drug molecules containing aryl-heteroaryl motifs.
doi_str_mv 10.1039/d1ob02201f
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title The synthesis of aryl-heteroaryl derivatives via the Rh III -catalyzed heteroarylation of arenes and heteroaromatic boronates
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