Turn-folding in fluorescent anthracene-substituted cyclopenta[]isoxazoline short peptides

Cyclopenta[ d ]isoxazoline aminols were used for the synthesis of β-turn mimics. The peptide chain choice ascertained the influence of their structural features on the applicability/reliability/robustness of these scaffolds as β-turn inducers and their limitations. The amino acid selection as well a...

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Bibliographic Details
Published in:RSC advances 2021-06, Vol.11 (32), p.19551-19559
Main Authors: Leusciatti, Marco, Mannucci, Barbara, Recca, Teresa, Quadrelli, Paolo
Format: Article
Language:English
Subjects:
Amino acids
Anthracene
Chains
Chemistry
Fluorescence
Folding
Peptides
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Summary:Cyclopenta[ d ]isoxazoline aminols were used for the synthesis of β-turn mimics. The peptide chain choice ascertained the influence of their structural features on the applicability/reliability/robustness of these scaffolds as β-turn inducers and their limitations. The amino acid selection as well as steric demands can favor or disfavor the structure folding and the correct design of the peptide chains deeply influences the potential use of these nitrosocarbonyl-based compounds as turn-inducers. Cyclopenta[ d ]isoxazoline aminols were used for the synthesis of β-turn mimics.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra03685h