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Engineered flavoproteins as bioorthogonal photo-triggers for the activation of metal-based anticancer prodrugs
A multifunctional hybrid constructed for controlling the delivery and activation of Pt anticancer agents in vitro is described herein. We employed consensus tetratricopeptide repeat protein (CTPR) for the covalent co-anchoring of riboflavin (photocatalyst) and a Pt( iv ) prodrug complex. The Pt-load...
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| Published in: | Chemical communications (Cambridge, England) England), 2023-04, Vol.59 (32), p.4754-4757 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c337t-56bce71ee41c62d41e39f38ec3df42469d689e921932a9e5ce6a12a8d40d55003 |
| container_end_page | 4757 |
| container_issue | 32 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 59 |
| creator | Mazzei, Laura F Gurruchaga-Pereda, Juan Martínez, Álvaro Martínez, Javier Calvo Salassa, Luca Cortajarena, Aitziber L |
| description | A multifunctional hybrid constructed for controlling the delivery and activation of Pt anticancer agents
in vitro
is described herein. We employed consensus tetratricopeptide repeat protein (CTPR) for the covalent co-anchoring of riboflavin (photocatalyst) and a Pt(
iv
) prodrug complex. The Pt-loaded flavoprotein induced a 40% reduction in PANC-1 cell viability as a result of the photocatalytic formation of cisplatin.
Riboflavin-functionalized repeat proteins enable controlling the photocatalytic activation and delivery of Pt anticancer agents
in vitro
. |
| doi_str_mv | 10.1039/d2cc06363h |
| format | article |
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in vitro
is described herein. We employed consensus tetratricopeptide repeat protein (CTPR) for the covalent co-anchoring of riboflavin (photocatalyst) and a Pt(
iv
) prodrug complex. The Pt-loaded flavoprotein induced a 40% reduction in PANC-1 cell viability as a result of the photocatalytic formation of cisplatin.
Riboflavin-functionalized repeat proteins enable controlling the photocatalytic activation and delivery of Pt anticancer agents
in vitro
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in vitro
is described herein. We employed consensus tetratricopeptide repeat protein (CTPR) for the covalent co-anchoring of riboflavin (photocatalyst) and a Pt(
iv
) prodrug complex. The Pt-loaded flavoprotein induced a 40% reduction in PANC-1 cell viability as a result of the photocatalytic formation of cisplatin.
Riboflavin-functionalized repeat proteins enable controlling the photocatalytic activation and delivery of Pt anticancer agents
in vitro
.</description><subject>Anticancer properties</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cisplatin</subject><subject>Flavoproteins</subject><subject>Photocatalysis</subject><subject>Prodrugs - pharmacology</subject><subject>Riboflavin</subject><subject>Riboflavin - pharmacology</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0c1LHDEYBvBQLLpue-ldCXiRwth87-Qo220tCF5a6G3IJu_MRmaTNckI_vfGrm7BXBLIjye8eRD6QskVJVx_c8xaorjimw9oRrkSjRTt36OXs9TNggt5gk5zvid1UdkeoxOu9EJoRWcorMLgA0ACh_vRPMZdigV8yNhkvPYxprKJQwxmxLtNLLEpyQ8DpIz7mHDZADa2-EdTfAw49ngLxYzN2uSaZ0Lx1gQLCddUl6Yhf0IfezNm-Py6z9GfH6vfy5vm9u7nr-X1bWM5X5RGqrWFBQUQ1CrmBAWue96C5a4XTCjtVKtBM6o5MxqkBWUoM60TxElJCJ-jy31uffhhgly6rc8WxtEEiFPuWEtY20pFVaUX7-h9nFIdeK-YZFKLqr7ulU0x5wR9t0t-a9JTR0n30kL3nS2X_1q4qfj8NXJab8Ed6Nu3V3C2Bynbw-3_GvkzC5WNcA</recordid><startdate>20230418</startdate><enddate>20230418</enddate><creator>Mazzei, Laura F</creator><creator>Gurruchaga-Pereda, Juan</creator><creator>Martínez, Álvaro</creator><creator>Martínez, Javier Calvo</creator><creator>Salassa, Luca</creator><creator>Cortajarena, Aitziber L</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8541-0839</orcidid><orcidid>https://orcid.org/0009-0005-6646-7943</orcidid><orcidid>https://orcid.org/0000-0002-0729-3809</orcidid><orcidid>https://orcid.org/0000-0001-9513-0518</orcidid><orcidid>https://orcid.org/0000-0002-2112-9095</orcidid><orcidid>https://orcid.org/0000-0002-5331-114X</orcidid></search><sort><creationdate>20230418</creationdate><title>Engineered flavoproteins as bioorthogonal photo-triggers for the activation of metal-based anticancer prodrugs</title><author>Mazzei, Laura F ; Gurruchaga-Pereda, Juan ; Martínez, Álvaro ; Martínez, Javier Calvo ; Salassa, Luca ; Cortajarena, Aitziber L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-56bce71ee41c62d41e39f38ec3df42469d689e921932a9e5ce6a12a8d40d55003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cisplatin</topic><topic>Flavoproteins</topic><topic>Photocatalysis</topic><topic>Prodrugs - pharmacology</topic><topic>Riboflavin</topic><topic>Riboflavin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazzei, Laura F</creatorcontrib><creatorcontrib>Gurruchaga-Pereda, Juan</creatorcontrib><creatorcontrib>Martínez, Álvaro</creatorcontrib><creatorcontrib>Martínez, Javier Calvo</creatorcontrib><creatorcontrib>Salassa, Luca</creatorcontrib><creatorcontrib>Cortajarena, Aitziber L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazzei, Laura F</au><au>Gurruchaga-Pereda, Juan</au><au>Martínez, Álvaro</au><au>Martínez, Javier Calvo</au><au>Salassa, Luca</au><au>Cortajarena, Aitziber L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineered flavoproteins as bioorthogonal photo-triggers for the activation of metal-based anticancer prodrugs</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2023-04-18</date><risdate>2023</risdate><volume>59</volume><issue>32</issue><spage>4754</spage><epage>4757</epage><pages>4754-4757</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A multifunctional hybrid constructed for controlling the delivery and activation of Pt anticancer agents
in vitro
is described herein. We employed consensus tetratricopeptide repeat protein (CTPR) for the covalent co-anchoring of riboflavin (photocatalyst) and a Pt(
iv
) prodrug complex. The Pt-loaded flavoprotein induced a 40% reduction in PANC-1 cell viability as a result of the photocatalytic formation of cisplatin.
Riboflavin-functionalized repeat proteins enable controlling the photocatalytic activation and delivery of Pt anticancer agents
in vitro
.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36974961</pmid><doi>10.1039/d2cc06363h</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8541-0839</orcidid><orcidid>https://orcid.org/0009-0005-6646-7943</orcidid><orcidid>https://orcid.org/0000-0002-0729-3809</orcidid><orcidid>https://orcid.org/0000-0001-9513-0518</orcidid><orcidid>https://orcid.org/0000-0002-2112-9095</orcidid><orcidid>https://orcid.org/0000-0002-5331-114X</orcidid></addata></record> |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2023-04, Vol.59 (32), p.4754-4757 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Anticancer properties Antineoplastic Agents - pharmacology Cell Line, Tumor Cisplatin Flavoproteins Photocatalysis Prodrugs - pharmacology Riboflavin Riboflavin - pharmacology |
| title | Engineered flavoproteins as bioorthogonal photo-triggers for the activation of metal-based anticancer prodrugs |
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