Solvent induced conformational polymorphism

The fact that the polymorphic outcome of crystallization is the result of the interplay between the relative thermodynamic stability and nucleation kinetics is well known. This paper presents the synthesis of 2,5-bis(3-bromophenyl)furan ( MBPF ), for which three polymorphic structures were obtained....

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Bibliographic Details
Published in:CrystEngComm 2023-02, Vol.25 (6), p.971-98
Main Authors: Dyk, Konrad, Kinzhybalo, Vasyl, Czernel, Grzegorz, Grudzi ski, Wojciech, Horak, Yuriy, Butenko, Serhii, Kami ski, Daniel M
Format: Article
Language:English
Subjects:
Crystal growth
Crystallization
Dichroism
Metastable phases
Nucleation
Polymorphism
Single crystals
Solvent effect
Spectroscopy
Stability
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Summary:The fact that the polymorphic outcome of crystallization is the result of the interplay between the relative thermodynamic stability and nucleation kinetics is well known. This paper presents the synthesis of 2,5-bis(3-bromophenyl)furan ( MBPF ), for which three polymorphic structures were obtained. The studies included: investigations of three polymorphic structures of this compound using single crystal X-ray diffraction, UV-Vis spectroscopy, circular dichroism spectroscopy, and theoretical approaches. The most important experimental result is the solvent effect on the MBPF conformation stability and in consequence on the crystal growth of the metastable phase. The fact that the polymorphic outcome of crystallization is the result of the interplay between the relative thermodynamic stability and nucleation kinetics is well known.
ISSN:1466-8033
1466-8033
DOI:10.1039/d2ce01681h