Fu brick tea alleviates alcoholic liver injury by modulating the gut microbiota-liver axis and inhibiting the hepatic TLR4/NF-κB signaling pathway

This study first evaluated the protective effects of Fu brick tea water extracts (FTE) on alcoholic liver injury and its underlying mechanism in C57BL/6J mice. Oral administration of FTE by oral gavage (400 mg per kg bw) for 12 weeks significantly alleviated lipid metabolism disorder, reduced the ac...

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Bibliographic Details
Published in:Food & function 2022-09, Vol.13 (18), p.9391-946
Main Authors: Du, Yao, Yang, Chengcheng, Ren, Daoyuan, Shao, Hongjun, Zhao, Yan, Yang, Xingbin
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Bricks
Cecum
Construction materials
CYP2E1 gene
Dysbacteriosis
Fatty acids
Injuries
Intestinal microflora
Lipid metabolism
Lipids
Lipopolysaccharides
Liver
Microbiota
NF-κB protein
Oral administration
Oxidation
Probiotics
Signal transduction
Signaling
Tea
TLR4 protein
Toll-like receptors
Tryptophan
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Summary:This study first evaluated the protective effects of Fu brick tea water extracts (FTE) on alcoholic liver injury and its underlying mechanism in C57BL/6J mice. Oral administration of FTE by oral gavage (400 mg per kg bw) for 12 weeks significantly alleviated lipid metabolism disorder, reduced the activities of serum ALT and AST, decreased the expression of the liver CYP2E1 gene, and enhanced the antioxidant capacities of the livers in alcohol-fed mice ( p < 0.05). FTE also relieved alcohol-induced gut microbiota dysbiosis by promoting the proliferation of probiotics such as Muribaculaceae and Lactobacillus , and subsequently increased the cecal levels of short-chain fatty acids (SCFAs) and decreased the tryptophan content of alcohol-fed mice ( p < 0.05). Importantly, FTE was found to improve the alcohol-impaired gut barrier function by up-regulating the expression of the epithelial tight junction protein. Accordingly, FTE decreased the circulating lipopolysaccharide (LPS) and thus inhibited the hepatic TLR4/NF-κB signaling pathway to ameliorate alcoholic liver injury. Cumulatively, these findings shed light on the important role of the gut microbiota-liver axis behind the protective efficacy of FTE on alcoholic liver injury. We evaluated the protective effects of Fu brick tea water extracts (FTE) on alcoholic liver injury and its underlying mechanism in C57BL/6J mice. The results suggested that FTE treatment effectively suppressed alcoholic liver injury.
ISSN:2042-6496
2042-650X
DOI:10.1039/d2fo01547a