The complete change in bile acids and steroids in systematic metabolomics applied to the intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific hepatobiliary disease, leading to an abnormal increase in total bile acid in the blood of pregnant women. To systematically explore the similarities and differences in metabolites and metabolic pathways among three types of biologic...

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Published in:Molecular omics 2023-06, Vol.19 (5), p.418-428
Main Authors: Xu, Hualin, Xu, Yupin, Zhao, Guoqiang, Fu, Xukun, Zhao, Jian, Wang, Huaqian, Cai, Yuliang, Lin, Hongmei
Format: Article
Language:English
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Summary:Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific hepatobiliary disease, leading to an abnormal increase in total bile acid in the blood of pregnant women. To systematically explore the similarities and differences in metabolites and metabolic pathways among three types of biological samples from ICP women, a study of 18 ICP and 6 healthy (as a normal control) pregnant women was performed to investigate their clinical information and biochemical features. Based on validated LC-MS/MS methods 1-5 for hydrophilic and hydrophobic metabolites (molecular weight
ISSN:2515-4184
2515-4184
DOI:10.1039/d2mo00305h