Smart green CQD@SiO 2 hybrid coated optical fiber manifesting dual versatile absorptive and MIP features towards epinephrine detection

• Published in: Nanoscale advances 2023-01, Vol.5 (2), p.459-470
• Main Authors: Azargoshasb, T, Parvizi, R, Bozorgzadeh, F, Navid, H Ali, Heidari, H
• Format: Article
• Language: English
• ISSN: 2516-0230; 2516-0230
• DOI: 10.1039/d2na00687a

For the first time, in this study, a novel optical fiber biosensor is proposed and developed coating only one smart functional layer of silica-supported carbon dots realizing the concepts of both lossy mode resonance (LMR) and molecularly imprinted polymer (MIP) for epinephrine detection. The carbon quantum dots (CQDs) are prepared using a green synthesis method and then treated with a molecularly imprinted polymer (MIP) strategy. Under ultrasonic irradiation, a SiO shell was stabilized on the surface of the CQDs to graft and to provide the LMR/MIP functional layer onto the curved optical fiber surface. Accurate structural and morphological characterization confirmed the carbon quantum dot agents and also the SiO supporting shells on the optical fiber, while spectroscopic analysis confirms the formation of the imprinted polymer and desirable absorbance characteristics. The experimental and numerical sensing studies revealed that the proposed sensing probe allows the rapid adsorption/desorption of epinephrine to the sensing films and highly permeable coating for studying the influence of effective parameters. Under the optimal experimental conditions, the sensitivity of the proposed LMR-based optical fiber sensor is reported to be 0.37 nm μM with a correlation coefficient of 0.99. So, sensitive detection of epinephrine at a low concentration can be guaranteed with a 0.72 mM LOD.