Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer

Nanocarriers have emerged as one of the most promising approaches for drug delivery. Although several nanomaterials have been approved for clinical use, the translation from lab to clinic remains challenging. However, by implementing rational design strategies and using relevant models for their val...

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Bibliographic Details
Published in:Nanoscale 2022-05, Vol.14 (17), p.6656-6669
Main Authors: Popov, Andrea Bistrovi, Melle, Francesca, Linnane, Emily, González-López, Cristina, Ahmed, Ishtiaq, Parshad, Badri, Franck, Christoph O, Rahmoune, Hassan, Richards, Frances M, Muñoz-Espín, Daniel, Jodrell, Duncan I, Fairen-Jimenez, David, Fruk, Ljiljana
Format: Article
Language:English
Subjects:
Cancer
Chemical compounds
Chemistry
Drug carriers
Drug Carriers - metabolism
Drug Delivery Systems
Heterogeneity
Histocompatibility
Humans
Melanin
Metabolites
Nanomaterials
Nanoparticles
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pharmacology
Poloxamers
Polymers
Tumor Microenvironment
Tumors
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Summary:Nanocarriers have emerged as one of the most promising approaches for drug delivery. Although several nanomaterials have been approved for clinical use, the translation from lab to clinic remains challenging. However, by implementing rational design strategies and using relevant models for their validation, these challenges are being addressed. This work describes the design of novel immunocompatible polymer nanocarriers made of melanin-mimetic polydopamine and Pluronic F127 units. The nanocarrier preparation was conducted under mild conditions, using a highly reproducible method that was tuned to provide a range of particle sizes (
ISSN:2040-3364
2040-3372
DOI:10.1039/d2nr00864e