Cu-catalyzed oxidative denitrogenation of 3-aminoindazoles for the synthesis of isoquinolinones

A Cu-catalyzed oxidative dual arylation of active alkenes via the cleavage of two C-N bonds of 3-aminoindazoles is presented for constructing isoquinolinones. Importantly, 3-aminoindazoles are used as efficient arylating agents through a radical process. This method has a good substrate scope and fu...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-08, Vol.2 (34), p.6844-6853
Main Authors: Guo, Yang, Huang, Peng-Fei, Xiong, Bi-Quan, Fan, Jian-Hong, Liu, Yu
Format: Article
Language:English
Subjects:
Alkenes
Chemical synthesis
Denitrogenation
Functional groups
Substrates
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Summary:A Cu-catalyzed oxidative dual arylation of active alkenes via the cleavage of two C-N bonds of 3-aminoindazoles is presented for constructing isoquinolinones. Importantly, 3-aminoindazoles are used as efficient arylating agents through a radical process. This method has a good substrate scope and functional group compatibility. A Cu-catalyzed oxidative dual arylation of active alkenes via the cleavage of two C-N bonds of 3-aminoindazoles is presented for constructing isoquinolinones.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01207c