A facile and light-controllable drug combination for enhanced photopharmacology

We investigated the feasibility of creating cyclic azobenzene/azobenzene-based photo-switchable drugs that can fine-tune antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) with light dependence. Furthermore, a "light-controlled drug combination&q...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-02, Vol.21 (5), p.121-126
Main Authors: Du, Guangxi, Fu, Jielin, Zheng, Yuanqin, Hu, Fuqiang, Shen, Xin, Li, Baolin, Zhao, Xiaohu, Yu, Zhipeng
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibiotics
Antimicrobial activity
Azo compounds
Controllability
Drug Combinations
Drug delivery
E coli
Escherichia coli
Light
Light effects
Microbial Sensitivity Tests
Staphylococcus aureus
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Summary:We investigated the feasibility of creating cyclic azobenzene/azobenzene-based photo-switchable drugs that can fine-tune antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) with light dependence. Furthermore, a "light-controlled drug combination" of these obtained drugs could be reversibly controlled to efficiently improve the antibiotic effect so as to reduce the minimum inhibitory concentrations (MICs) with different wavelength light illumination. Importantly, their antimicrobial activity could be easily manipulated by using light in bacterial patterning studies with high spatiotemporal precision, which might allow for localized activation of drugs and provide an alternative solution for practical clinical application in photopharmacology. The visible light-regulated drug combination of DBTDA-fused floxacin and azobenzene-linked sulfadiazine against S. aureus.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob02190k