A new reversible transformation of oxindolylidene derivatives of imidazothiazolotriazine into 3-[(imidazotriazin-3-yl)thio]-2-oxoquinoline-4-carboxylates

A simple method for the synthesis of water-soluble potassium 3-[(imidazotriazin-3-yl)thio]-2-oxoquinoline-4-carboxylates was developed based on a new reversible transformation of oxindolylidene derivatives of imidazothiazolotriazine that results from their treatment with potassium hydroxide. The ant...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-02, Vol.21 (8), p.1827-1834
Main Authors: Izmest'ev, Alexei N, Kravchenko, Angelina N, Gazieva, Galina A
Format: Article
Language:English
Subjects:
Antiproliferatives
Carboxylates
Cell lines
Potassium
Potassium hydroxide
Potassium hydroxides
Quinoline
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Summary:A simple method for the synthesis of water-soluble potassium 3-[(imidazotriazin-3-yl)thio]-2-oxoquinoline-4-carboxylates was developed based on a new reversible transformation of oxindolylidene derivatives of imidazothiazolotriazine that results from their treatment with potassium hydroxide. The antiproliferative activity of the synthesized compounds was evaluated against 58 cell lines and compared with oxindolylidene derivatives of imidazothiazolotriazine. Quinoline derivatives 3 demonstrated high activity with average GI 50 values of
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob02242g