Loading…

Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy

C 60 -fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we inve...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2022-08, Vol.12 (34), p.22197-2221
Main Authors: Ruan, Hefei, Zhang, Xuejie, Yuan, Jinghe, Fang, Xiaohong
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:C 60 -fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples. Nanoscale morphological changes of macrophages characterized by contact-free SICM and their relationship with phagocytosis after C 60 -fullerene treatment demonstrate they are a potential phagocytosis inhibitor.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra02403a