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Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
C 60 -fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we inve...
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| Published in: | RSC advances 2022-08, Vol.12 (34), p.22197-2221 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 2221 |
| container_issue | 34 |
| container_start_page | 22197 |
| container_title | RSC advances |
| container_volume | 12 |
| creator | Ruan, Hefei Zhang, Xuejie Yuan, Jinghe Fang, Xiaohong |
| description | C
60
-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
Nanoscale morphological changes of macrophages characterized by contact-free SICM and their relationship with phagocytosis after C
60
-fullerene treatment demonstrate they are a potential phagocytosis inhibitor. |
| doi_str_mv | 10.1039/d2ra02403a |
| format | article |
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60
-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
Nanoscale morphological changes of macrophages characterized by contact-free SICM and their relationship with phagocytosis after C
60
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60
-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
Nanoscale morphological changes of macrophages characterized by contact-free SICM and their relationship with phagocytosis after C
60
-fullerene treatment demonstrate they are a potential phagocytosis inhibitor.</description><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Fullerenes</subject><subject>Macrophages</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Photodynamic therapy</subject><subject>Water chemistry</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkctrFTEUxoMottRu3AsBNyKMZpJMZrIRLm19QEEQXYc8Tm6nZJJrMmm5_7253lIfZ5MD-X1fTs6H0MuevOsJk-8dzZpQTph-gk4p4aKjRMinf_Un6LyUW9JKDD0V_XN0wgThrMlP0f2V92BXnDy-1yvkrqRQTQDsawiQIULBKeJF25x2N3oLuNTstQVcw5p1WXO1a82AM9yBDuCw2eNidYxz3OK5SW2KrjE6Ns0yN5ti027_Aj3zOhQ4fzjP0I-PV98vPnfXXz99udhcd5YJvnbDxKTlvZGOcTZ5Lp321AopZD9ME3N-NNqYcXCWCCIJtdz0E5ncwI0lfCDsDH04-u6qWcBZiG3qoHZ5XnTeq6Rn9e9NnG_UNt0p2d4n49QM3jwY5PSzQlnVMhcLIegIqRZFRzKNjPGRN_T1f-htqjm27x0oJtvuCW3U2yN1WEXJ4B-H6Yk6RKou6bfN70g3DX51hHOxj9yfyNkvhDmeQQ</recordid><startdate>20220810</startdate><enddate>20220810</enddate><creator>Ruan, Hefei</creator><creator>Zhang, Xuejie</creator><creator>Yuan, Jinghe</creator><creator>Fang, Xiaohong</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2018-0542</orcidid><orcidid>https://orcid.org/0000-0003-3016-3540</orcidid></search><sort><creationdate>20220810</creationdate><title>Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy</title><author>Ruan, Hefei ; Zhang, Xuejie ; Yuan, Jinghe ; Fang, Xiaohong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-5839c41b9d3438f49daf2c696915883df7babb75dc060902c4b1808d54bc04503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Fullerenes</topic><topic>Macrophages</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Photodynamic therapy</topic><topic>Water chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruan, Hefei</creatorcontrib><creatorcontrib>Zhang, Xuejie</creatorcontrib><creatorcontrib>Yuan, Jinghe</creatorcontrib><creatorcontrib>Fang, Xiaohong</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruan, Hefei</au><au>Zhang, Xuejie</au><au>Yuan, Jinghe</au><au>Fang, Xiaohong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy</atitle><jtitle>RSC advances</jtitle><date>2022-08-10</date><risdate>2022</risdate><volume>12</volume><issue>34</issue><spage>22197</spage><epage>2221</epage><pages>22197-2221</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>C
60
-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
Nanoscale morphological changes of macrophages characterized by contact-free SICM and their relationship with phagocytosis after C
60
-fullerene treatment demonstrate they are a potential phagocytosis inhibitor.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>36043103</pmid><doi>10.1039/d2ra02403a</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2018-0542</orcidid><orcidid>https://orcid.org/0000-0003-3016-3540</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2022-08, Vol.12 (34), p.22197-2221 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D2RA02403A |
| source | Open Access: PubMed Central |
| subjects | Biomedical materials Chemistry Fullerenes Macrophages Microscopy Morphology Photodynamic therapy Water chemistry |
| title | Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy |
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