Allium sativum @AgNPs and Phyllanthus urinaria @AgNPs: a comparative analysis for antibacterial application

Although medicinal herbs contain many biologically active ingredients that can act as antibiotic agents, most of them are difficult to dissolve in lipids and absorb through biofilms in the gastrointestinal tract. Besides, silver nanoparticles (AgNPs) have been widely used as a potential antibacteria...

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Bibliographic Details
Published in:RSC advances 2022-12, Vol.12 (55), p.35730-35743
Main Authors: Phan, Ke Son, Nguyen, Thi Minh, To, Xuan Thang, Le, Thi Thu Huong, Nguyen, Thanh Trung, Pham, Kim Dang, Hoang, Phuong Ha, Dong, Thi Nham, Dang, Dinh Kim, Phan, Thi Hong Tuyet, Mai, Thi Thu Trang, Ha, Phuong Thu
Format: Article
Language:English
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Summary:Although medicinal herbs contain many biologically active ingredients that can act as antibiotic agents, most of them are difficult to dissolve in lipids and absorb through biofilms in the gastrointestinal tract. Besides, silver nanoparticles (AgNPs) have been widely used as a potential antibacterial agent, however, to achieve a bactericidal effect, high concentrations are required. In this work, AgNPs were combined into plant-based antibiotic nanoemulsions using biocompatible alginate/carboxyl methylcellulose scaffolds. The silver nanoparticles were prepared by a green method with an aqueous extract of or extract. The botanical antibiotic components in the alcoholic extract of these plants were encapsulated with emulsifier poloxamer 407 to reduce the particle size, and make the active ingredients both water-soluble and lipid-soluble. Field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray (EDX) analysis showed that the prepared nanosystems were spherical with a size of about 20 nm. Fourier transform infrared spectroscopy (FTIR) confirmed the interaction of the extracts and the alginate/carboxyl methylcellulose carrier. drug release kinetics of allicin and phyllanthin from the nanosystems exhibited a retarded release under different biological pH conditions. The antimicrobial activity of the synthesized nanoformulations were tested against . The results showed that the nanosystem based on possesses a significantly higher antimicrobial activity against the tested organisms. Therefore, the combination of AgNPs with active compounds from extract is a good candidate for infection treatment application.
ISSN:2046-2069
2046-2069
DOI:10.1039/D2RA06847H