Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

A heavy-atom-free photosensitizer ( CI ) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-04, Vol.59 (3), p.453-456
Main Authors: Pham, Thanh Chung, Lee, Dong Joon, Kim, Do Hun, Yoon, Juyoung, Lam, Tran Dai, Kim, Hwan Myung, Lee, Songyi
Format: Article
Language:English
Subjects:
Carbazoles
Conjugates
Fluorescence
HeLa Cells
Humans
Imidazole
Imidazoles
Medical imaging
Photochemotherapy - methods
Photodynamic therapy
Photons
Toxicity
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Summary:A heavy-atom-free photosensitizer ( CI ) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity. A heavy-atom-free photosensitizer ( CI ) showed strong singlet oxygen generation, efficient photodynamic therapy and fluorescence bioimaging under two-photon excitation.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00108c