Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy

An ultra-selective 1D NMR experiment - GEMSTONE-ROESY - enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto- N -difucohexaose I, provid...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-05, Vol.59 (39), p.5854-5857
Main Authors: Gates, Emma L, Smith, Marshall J, Bradley, Jonathan P, Johnson, Myron, Widmalm, Göran, Nilsson, Mathias, Morris, Gareth A, Adams, Ralph W, Castañar, Laura
Format: Article
Language:English
Subjects:
Gems
Natural products
NMR
Nuclear magnetic resonance
Overhauser effect
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Summary:An ultra-selective 1D NMR experiment - GEMSTONE-ROESY - enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto- N -difucohexaose I, providing detailed insight into the structures and conformations of these molecules. A new ultra-selective 1D ROESY method which enables clear, unambiguous assignment of through-space interactions, providing insight into 3D structure and conformation.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d3cc00550j