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Chemical remodeling of the mycomembrane with chain-truncated lipids sensitizes mycobacteria to rifampicin
The outer mycomembrane of Mycobacterium tuberculosis and related pathogens is a robust permeability barrier that protects against antibiotic treatment. Here, we demonstrate that synthetic analogues of the mycomembrane biosynthetic precursor trehalose monomycolate bearing truncated lipid chains incre...
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| Published in: | Chemical communications (Cambridge, England) England), 2023-11, Vol.59 (93), p.13859-13862 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c352t-161948baad72140f1ee5b489e85f1b4ffc6bed213054a6da26ff9b5c2eccbe403 |
| container_end_page | 13862 |
| container_issue | 93 |
| container_start_page | 13859 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 59 |
| creator | Gaidhane, Ishani V Biegas, Kyle J Erickson, Helen E Agarwal, Prachi Chhonker, Yashpal S Ronning, Donald R Swarts, Benjamin M |
| description | The outer mycomembrane of
Mycobacterium tuberculosis
and related pathogens is a robust permeability barrier that protects against antibiotic treatment. Here, we demonstrate that synthetic analogues of the mycomembrane biosynthetic precursor trehalose monomycolate bearing truncated lipid chains increase permeability of
Mycobacterium smegmatis
cells and sensitize them to treatment with the first-line anti-tubercular drug rifampicin. The reported strategy may be useful for enhancing entry of drugs and other molecules to mycobacterial cells, and represents a new way to study mycomembrane structure and function.
Remodeling the notoriously impenetrable mycobacterial outer membrane with synthetic lipids enhances cellular permeability, sensitizing bacteria to the clinically used antibiotic rifampicin. |
| doi_str_mv | 10.1039/d3cc02364h |
| format | article |
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Mycobacterium tuberculosis
and related pathogens is a robust permeability barrier that protects against antibiotic treatment. Here, we demonstrate that synthetic analogues of the mycomembrane biosynthetic precursor trehalose monomycolate bearing truncated lipid chains increase permeability of
Mycobacterium smegmatis
cells and sensitize them to treatment with the first-line anti-tubercular drug rifampicin. The reported strategy may be useful for enhancing entry of drugs and other molecules to mycobacterial cells, and represents a new way to study mycomembrane structure and function.
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Mycobacterium tuberculosis
and related pathogens is a robust permeability barrier that protects against antibiotic treatment. Here, we demonstrate that synthetic analogues of the mycomembrane biosynthetic precursor trehalose monomycolate bearing truncated lipid chains increase permeability of
Mycobacterium smegmatis
cells and sensitize them to treatment with the first-line anti-tubercular drug rifampicin. The reported strategy may be useful for enhancing entry of drugs and other molecules to mycobacterial cells, and represents a new way to study mycomembrane structure and function.
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Mycobacterium tuberculosis
and related pathogens is a robust permeability barrier that protects against antibiotic treatment. Here, we demonstrate that synthetic analogues of the mycomembrane biosynthetic precursor trehalose monomycolate bearing truncated lipid chains increase permeability of
Mycobacterium smegmatis
cells and sensitize them to treatment with the first-line anti-tubercular drug rifampicin. The reported strategy may be useful for enhancing entry of drugs and other molecules to mycobacterial cells, and represents a new way to study mycomembrane structure and function.
Remodeling the notoriously impenetrable mycobacterial outer membrane with synthetic lipids enhances cellular permeability, sensitizing bacteria to the clinically used antibiotic rifampicin.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37929833</pmid><doi>10.1039/d3cc02364h</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-8402-359X</orcidid><orcidid>https://orcid.org/0000-0003-2583-8849</orcidid></addata></record> |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2023-11, Vol.59 (93), p.13859-13862 |
| issn | 1359-7345 1364-548X 1364-548X |
| language | eng |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Cell Membrane - chemistry Cell Wall Lipids Lipids - analysis Mycobacterium tuberculosis - chemistry Permeability Rifampin - pharmacology Trehalose |
| title | Chemical remodeling of the mycomembrane with chain-truncated lipids sensitizes mycobacteria to rifampicin |
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