Base-free regio- and stereoselective photochemical synthesis of enol ethers from 1,3-dicarbonyl compounds

A visible light-induced kinetic controlled regioselective O -alkylation of various 1,3-dicarbonyl compounds with diazoacetates and cyclic ethers has been developed. The protocol provides a green and practical approach to highly stereoselective enol ethers under mild and base-free conditions in good...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-10, Vol.59 (84), p.1265-1268
Main Authors: Zhu, Keyong, Yu, Wen-Jing, Zhou, Xinlong, Xu, Chaogui, Zhao, Guanzhen, Chai, Yun, Li, Shi-Jun, Xu, Yuanqing, Li, Pan
Format: Article
Language:English
Subjects:
Alkylation
Carbonyl compounds
Ethers
Stereoselectivity
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Summary:A visible light-induced kinetic controlled regioselective O -alkylation of various 1,3-dicarbonyl compounds with diazoacetates and cyclic ethers has been developed. The protocol provides a green and practical approach to highly stereoselective enol ethers under mild and base-free conditions in good to excellent yields. A visible light-induced kinetic controlled regioselective O -alkylation of various 1,3-dicarbonyl compounds with diazoacetates and cyclic ethers has been developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc03317a