Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-08, Vol.59 (71), p.166-1663
Main Authors: Chan, Ai-Ci, Shan, Pei-Ya, Wu, Men-Hsin, Lin, Pin-Han, Tsai, Chang-Shun, Hsu, Chia-Chien, Chiu, Ting-Hsiang, Hsu, Ting-Wei, Yeh, Yi-Cheun, Lai, Yun-Ju, Liu, Wei-Min, Tu, Ling-Hsien
Format: Article
Language:English
Subjects:
Nucleation
Polypeptides
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Summary:Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity. PAD-13 interacts with IAPP, accelerates IAPP aggregation, and modulates the antimicrobial activity of IAPP.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc03363e