Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs

Cancer has become the second leading reason for death in the world. Still, cancer therapy development is exceptionally challenging because the tumor microenvironment is very complex, and individual tumors are very different. In recent years, researchers have found that platinum-based drugs in the fo...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2023-05, Vol.52 (19), p.6226-6238
Main Authors: Chen, Jinyi, Zhang, Zhixin, Ma, Jiaxin, Nezamzadeh-Ejhieh, Alireza, Lu, Chengyu, Pan, Ying, Liu, Jianqiang, Bai, Zhi
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - pharmacology
Coordination compounds
Drugs
Humans
Metal-Organic Frameworks
Neoplasms - drug therapy
Platinum
Tumor Microenvironment
Tumors
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Summary:Cancer has become the second leading reason for death in the world. Still, cancer therapy development is exceptionally challenging because the tumor microenvironment is very complex, and individual tumors are very different. In recent years, researchers have found that platinum-based drugs in the form of metal complexes can effectively solve tumor resistance. In this regard, metal-organic frameworks (MOFs) as suitable carriers with high porosity are also exceptional in the biomedical field. Therefore, this article reviews the application of platinum as an anticancer drug and the composite anticancer properties of platinum and MOF materials and prospects for its future development, which provides a new direction for further research in the biomedical field. This review focuses on the application of platinum as an anticancer drug and the MOF materials loading platinum species; the prospect for its future development is also discussed.
ISSN:1477-9226
1477-9234
DOI:10.1039/d3dt00413a