Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

A solvent-tuned electrochemical protocol for the selective transfer hydrogenation of imidazopyridines using carbazates as hydrogen donors has been developed. This electrosynthesis strategy provides a more sustainable and greener way to access partially saturated N-heterocycles by avoiding traditiona...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2023-11, Vol.25 (23), p.975-971
Main Authors: Tang, Zhicong, Hong, Gang, Chen, Jian, Huang, Ting, Zhou, Zichao, Wang, Limin
Format: Article
Language:English
Subjects:
Catalysts
Electrochemistry
Green chemistry
Hydrogen
Hydrogenation
Solvents
Transition metals
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Summary:A solvent-tuned electrochemical protocol for the selective transfer hydrogenation of imidazopyridines using carbazates as hydrogen donors has been developed. This electrosynthesis strategy provides a more sustainable and greener way to access partially saturated N-heterocycles by avoiding traditionally employed transition metal catalysts and high-pressure hydrogen. Remarkably, the method is scalable and applicable to late-stage functionalization of complex molecules. A possible mechanism has been proposed on the basis of radical-trapping and cyclic voltammetry experiments. A solvent-tuned electrochemical protocol for the selective transfer hydrogenation of imidazopyridines using carbazates as hydrogen donors has been developed.
ISSN:1463-9262
1463-9270
DOI:10.1039/d3gc03389a